Repbase Reports
2007, Volume 7, Issue 4
April 30, 2007
Copyright © 2001-2024 - Genetic Information Research Institute, California
ISSN# 1534-830X
Page 144

IS4EU-1_BF

A family of autonomous IS4EU transposons - a consensus.

Submitted:
29-Apr-2007 		Accepted:
01-MAY-2007
Key Words:
ISL2EU; DNA transposon; Transposable Element; IS4EU; Interspersed repeat; DNA-TA-7_BF; IS4EU-1_BF
Source:
Branchiostoma floridae 		Organism:
Branchiostoma floridae 		Taxonomy:
Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma
[] Authors:
Kapitonov,V.V. and Jurka,J.
Title:
IS4EU, a novel superfamily of eukaryotic DNA transposons.
Journal:
Repbase Reports 7(4), 144-144 (2007)
Abstract:
DNA transposons from the IS4EU superfamily are characterized by the TA target site duplications. These transposons are wide spread in metazoans, including fish, frogs, lancelet, sea urchins, sea squirts, insects and cnidarians. Autonomous IS4EU transposons encode two proteins: the IS4EU-TR transposase, which is similar to the IS4-like bacterial transposases, and the ISEU-EX DNA exonuclease (lambda-like exonuclease). Based on the conservation of both proteins in highly divergent transposons, is is clear that they are necessary for transpositions. IS4EU-1_BF is a consensus sequence of a young family of autonomous IS4EU transposons that were active in the lancelet genome in a last few million years. The IS4EU-1_BF transposon is characterized by 11-bp imperfect terminal inverted repeats, TA target site duplications, ATAT target sites; and it encodes two proteins: (i) the 426-aa transposase, IS4EU-1_BF1p, composed of the THAP DNA-binding N-terminal domain and catalytic "DDE" domain, which is conserved in all IS4EU transposases, and (ii) the 512-aa IS4EU-1_BF2p exonuclease, including the PHD zinc finger. Questions and comments send to Vladimir Kapitonov.
Derived:
[1] (Consensus)
Download Sequence - Format:
IG, EMBL, FASTA
References:

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